[Eavaluation of antinociceptic effect of nano-emulsion gel conataining rosemary and peppermint essential oils in a rat model of osteoarthritis]

ABSTRACT

Background and Aim: despite identification of the antinociceptive effects of rosemary and peppermint essential oils, use of these essential oils has been limited due to its low solubility in water and low bioavailability. Use of nanoparticles is one of the ways to overcome these limitations. The aim of this study was to evaluate the antinociceptive effect of nano-emulsions containing rosemary and peppermint essential oils in an animal model of osteoarthritis [OA]