Effect of catsper and HV1 channel inhibition on progesterone stimulated human sperm

ABSTRACT

Background: intracellular calcium and proton concentrations are important factors for activating human sperm. Calcium ion [Ca2+] enters sperm through voltagedependent calcium channel of sperm [CatSper]. Proton was extruded from sperm through voltage-gated proton channel [Hv1]. In the present study, the selective inhibitors of the CatSper and Hv1 channels, NNC 55-0396 [NNC] and zinc ion, respectively, were used to investigate functions of these channels