Evaluation of some biological activities of the alcoholic extracts of Salsola volkensii and Salsola villosa in rats

ABSTRACT

Plant products, having traditional medicinal values have always been an interesting to the phytochemists and pharmacologist. The LD50, hepatoprotective, anti-inflammatory, analgesic, ulcerogenie activities and the effect on liver and kidney functions of the alcoholic extracts of Salsola volkensii [S.I.]125 mg/ 100g and Salsola villosa [S.II]154mg/ 100g were carried out in normal and carbon tetrachloride [CCI4] treated rats. Results obtained revealed that both tested extracts were non toxic when orally administred to mice. Oral pre-treatment with 125,154 mg/ 100 g of S.I. and S.II. Alcoholic extract for 8 days and 2 days post-CCI4 treatment significantly attenuated the elevation of serum GOT, GPT, GGT, total bilirubin, direct and indirect bilirubin, urea, and creatinine. In normal rats treated with S.I. and S. II. Alcoholic extracts exhibited a significant increase in total protein and decreased significantly total bilirubin, S. II. Extract decreased the indirect bilirubin. Both extracts inhibited paw edema induced by carrageenan by 52% and cotton pellets granuloma by 42%, 46.5% respectively, in addition to that they both posses an analgesic "in tail-electric stimulation assay" as well as ulcerogenic effect