Urinary N-acetyl-beta-D-glucosaminidase: as a marker for early detection of renal tubular disturbance in patients with IDDM [type 1]

ABSTRACT

Clinical diabetic nephropathy represents one of the major forms of microangiopathy complications of diabetes. This condition is associated with renal tubular as well as glomeruiar damage. The aim of this study is to N-acetyl-Beta-D glucosaminidase [NAG] and glomeruiar integrity was evaluate the level of NAG in IDDM patients [type1] and its relation to microalbuminuria, duration of diabetes and diabetic control. Tubular cell structural integrity was evaluated by measuring urinary measured by evaluating the level of microalbuminuria. in addition serum creatinine was evaluated as a common test for renal function. Moreover, the level of serum fructosamine and blood HbA1c were measured to assess the degree of the control of blood glucose along a short and long periods respectively. The study was done on three groups of male diabetic patients, type 1 [IDDM] according to disease duration. They were selected with aging up to 30 years old and of the same socioeconomic levels. In addition, age-matched healthy male persons were taken as controls. In conclusion, this study indicates that urinary NAG measurement is a sensitive, non-invasive test for early detection of diabetic patients at risk of developing diabetic nephropathy and as a good marker for long term period glycemic control in IDDM patients