[Mortality in juvenile idiopathic arthritis]

ABSTRACT

Mortality in juvenil Arthritis is variable from a serie to another and with form of IJA. The authors have analysed the observations of child dead by IJA. They report three observatios concerning 2 boys and 1 girl aged respectively of 7 years 10 months, 10 years 3 months ant 14 years 4 months which is compatible of a level mortality of 4, 2 % in the period of study [1986 -2003] IJA is polyarticular in the three patients, with systemic beginning in one boy and it's a spondylarthro pathy in the second. The etiology of death is a macrophagic activation syndrom in 2 cases revealed by neurologic and hemorragic symptoms. The association salazopyrin - acetyl slycylic acid is incriminated in one boy and rofecoxib in the girl. In the other boy death is secondary to renal amylodosis associated to nephritic syndrom, renal deficiency, denutrition and Ionic disorders. This amylodosis was pertisting, in spite of treatment by methotrexate for three months. The authors conclude to elevated level of mortality and insist on depistage and rapid treatment of macrophagic activation syndrome for the prognosis of IJA