[Comparitive study of matrix metalloproteinase [I and II] function on different fibroblast culture models]

ABSTRACT

Introduction: The process of wound healing sets in motion a complex and dynamic series of events, which includes the remodeling of the extracellular matrix degradation of matrix proteins, predominantly collagen fibers, mediated by matrix metalloproteinase [MMPs]. Our aim was to demonstrate whether fibroblasts derived from various strains of human fetal foreskin [FS] and adult skin [AS], when cultivated in a 3-D tissue model, exhibit different matrix metalloproteinase activities as compared to plastic environment