Aberrant expression of microRNAs 16 and 21 and gene targets in women with unexplained recurrent miscarriage: a case-control study

ABSTRACT

Background: Recurrent miscarriage, as the occurrence of two or more of pregnancy loss before the 20[th] wk, can occur for multiple causes. One of the causes of miscarriage may be a defect in the process of angiogenesis because the delivery of nutrients to the fetus is decreased and it may lead to miscarriage. Also, micro ribonucleic acids play an important role in the development of diseases. The microRNAs 16 and 21 are the most well-known angiogenesis-related miRNAs, which their gene targets are vascular endothelial growth factor-A and phosphatase and tensin homolog, respectively