Determination of red cell Antigen Alloimmunization and specific type of antibody in multi-transfused Liver Cirrhosis patient

ABSTRACT

Background: In liver cirrhosis anemia occurs in up to 75 percent of the patients and blood transfusion is the mainstay of treatment of anemia. Red cell alloimmunization is a common problem encountered in multi-transfused patient. Alloimmunization can make further blood transfusion troublesome as extensive matching of donor is required to provide antigen free blood to the recipient for which alloantibodies are formed. Antibodies to foreign red cell antigens in patient's blood results in delay of transfusion because of complex pre-transfusion tests and difficulty in finding compatible red blood cell unit. Moreover, they can also cause delayed hemolytic blood transfusion reaction