Comparison of wild type and mutated [mHuIFN- beta 27-101] Interferon binding to the IFNRA receptor by Molecular Docking

ABSTRACT

Introduction: Interferon beta is one of the members of type I interferons. Creating R27T and V101F mutations is one of the important researches performed to improve function, decrease immunogenicity, increase expression and increase half-life of interferon beta. In this study, the effects of R27T and V101F mutations on interferon beta binding to interferon receptors were studied by molecular docking