[Anti-emtic effect of Trachyspermum ammi L. fruit extracts in young chickens]

ABSTRACT

The anti-emetic effect of the aqueous and ethanolic extracts of Trachyspermum ammi fruit was studied in young chickens. Emesis was induced in the chickens using copper sulfate [60 mg/kg, orally] and ipecac [600 mg/kg, orally]. The LD50 values of the aqueous and ethanolic extracts [i.p.] were 2753 mg/kg and 747 mg/kg in the chickens, respectively. The aqueous extract [800-2000 mg/kg, i.p.] and ethanolic extract [40-100 mg/kg, i.p.] significantly prevented the emesis induced by copper sulfate and ipecac. These results indicate that the extracts of T. ammi fruit extracts have an anti-emetic activity in young chickens with peripheral and central mechanisms