[Evaluation of chimerism in interphase nuclei of peripheral blood of patients with sex-mismatch bone marrow transplantation]
Journal of Medical Council of Islamic Republic of Iran. 2004; 22 (3): 220-226
in Persian
| IMEMR
| ID: emr-206944
ABSTRACT
Fully quantitative cytological techniques for the analysis of hematopoietic chimerism are very limited and are largely restricted to sex - chromosome detection after sex - mismatched bone marrow transplants [BMTs]. The aim of the present investigation was to evaluate the application of FISH technique in peripheral blood interphase nuclei of three patients who had received sex - mismatched bone marrow transplants. The FISH technique shows 40% to 85% [average 61%] chimerism in these patients. All the three studied patients having undergone bone marrow transplants have achieved complete remission now. Evaluation of mixed chimerism has potential applications in controlling self-reactions avoiding rejection of the transplant
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Index:
IMEMR (Eastern Mediterranean)
Language:
Persian
Journal:
J. Med. Counc. Islam. Rep. Iran
Year:
2004
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