Synthesis and evaluation of calcium channel antagonist activity of new 1, 4- dihydropyridines containing phenylamineimidazolyl substitute in guinea-pig ileal smooth muscle

ABSTRACT

Background: 1,4-dihydropyridines are a class of drugs which are used in the treatment of some cardiovascular disorders. The prototype, Nifedipine, does not have optimal pharmacokinetic and pharmacodynamic properties. Several new derivatives of 1, 4-dihydropyridine have been produced and pharmacologically evaluated in order to find drugs with better pharmacological properties. Among them, those with a substituted heteroaromatic ring in the C4 position of the 1, 4-dihydropyridine ring, instead of the phenyl ring in Nifedipine, are most considered. In this study, eight novel derivatives of this class with "2-methylthio-1-[phenylamino]imidazole-5-yl" in the C4, C3 and C5 positions were prepared and evaluated as calcium channel antagonist agents