Utilization of chloranil in the spectrophotometric determination of certain amino compounds via charge-transfer complexion

ABSTRACT

Chloranil was utilized in the spectrophotometric determination of benzocaine, lignocaine hydrochloride and reserpine through charge-transfer complexation. The molar combining ratio and the optimum complexation conditions have been studied. The method was applied for the determination of the suggested compounds in bulk powders with mean percentage accuracies of 99.79 +/- 2.59, 100.43 +/- 2.324 and 97.75 +/- 1.561 for benzocaine, lignocaine hydrochloride, and reserpine, respectively. A comparative study between the suggested procedure and the pharmacopeia for these compounds in their pharmaceutical preparations showed no significant difference between the two methods: