role of angiotensin converting enzyme inhibitors on the prevention of myocardial necrosis in experimental animals

ABSTRACT

The present work is concerned with the study of the role of the angiotensin converting enzyme inhibitors [A. C. E. Is.], enalapril and captopril, in the preservation of the myocardium in isoprenaline-induced ischemic changes in rats. It was found that capftpril in a single dose could significantly reduce the percentage of ischemic changes. On the contrary, enalapril was insignificantly effective. On the other hand subacute [15 days] administration of enalapril could significantly reduce the percentage of myocardial necrosis, more than captopril in animals treated with the drug for the same period. It was concluded that the variability in the pharmacokinetics and hemodynamic effects of both drugs is the cause of difference in the response to each drug. Also,it was concluded that the A. C. E. Is. could be effective in treatment of hypertension with ischemic heart disease, through their coronary dilator effect, through inhibition of the angiotensin-renin system, and also, by the lack of unwanted effects on lipid metabolism