Immunohistochemical study of epithelial cell markers in inverted papilloma of the nose and paranasal sinuses

ABSTRACT

The expression of keratin, carcino embryonic antigen [C.E.A] and epithelial membrane antigen [E.M.A] were studied in the epithelial linings of 9 cases of inverted papilloma of the nose and para-nasal sinuses, using an indirect immunoperoxidase method on formaline fixed paraffin embedded sections 8 cases were positive with polyclonal antibodies of keratin specificity. The pattern of expression of C.E.A. and E.M.A. differed it was suprabasal in 7 cases with C.E.A. and basal in 5 cases with [E.M.A.] although these differences may not be of diagnostic significance, the constant expression of keratin may provide a useful marker of inverted papilloma