Effect of mazindol administration in lithium carbonate-treated rats on certain brain transmitters and metabolic aspects

ABSTRACT

Possible effects due to interaction between mazinodl and lithium carbonate have been studied on intact rats. Lithium carbonate [1 mmol/kg/day] was given orally for 13 successive days. Mazindol [2 mg/kg] either alone or in combination with lithium carbonate [1 mmol/kg/day] was given orally either at a single dose once ordaily for 3 successive days. Deception of rats has been carried out 3 hours after the single dose treatments and 24 hours after the repeated administration of drugs. Effects on some brain transmitters [norepinephrine, dopamine and 5-hydroxytrypatamine] as well as on serum glucose, insulin and corticosterone has been studied. Revealed that mazindol did not changes the effect of lithium carbonate on brain transmitters. However, mazindol, 3 hours, after its aministration, antagonized the effect of lithium carbonate on serum glucose and insulin. On the other hand mazindol potentiated the effect of lithium carbonate on serum glucose, insulin and corticosterone, when given for 3 successive days. This effect might be attributed to increased serum lithium carbonate level after repeated mazindol administration. It could be concluded that mazindol does not interfere with the effect of lithium carbonate on brain transmitters although it potentiated lithium carbonate effect on metabolic aspects studied