role of bacterial allergens in nasal polyposis and chronic perreneal allergic rhinits

ABSTRACT

Thirty six patients of chronic nasal polyposis and 30 patients of chronic allergic rhinitis as wall as 20 apparently healthy control subjects underwent tests for the presence of bacterial-specific I[g]E antibodies in the serum using the radioallerge-sorbent [RAST] assay. Twenty-two chronic polyposis patents exhibited a positive [mean titre of 5000 +/- 1249], prevalence rate of 61% [P< 0.001]. The mean bacterial specific I[g]E titre in chronic rhinitis group was much lower [2500 +/- 850], it was also statistically higher than the control group [P< 0.01]. This study indicates that allergy to bacterial antigens may play a significant role in the induction and development of chronic nasal polyposis