EEG and ECG observation in acute uremia

ABSTRACT

Acute uremia was induced in rats by glycerol injection. After 10 hours, EEG and ECG tracings were recorded and serum creatinine, Na[+] and K[+] in both normal and uremic rats were measured. With uremia, EEG become abnormally slow i.e percentage frequency of slow waves [<5 H[2]] was increased with simultaneous decrease in% frequency of fast waves [>9 H[2]]. In addition, charateristic slow delta waves were recorded. ECG recording showed less characteristic change with prolonged P-R interval, decreased QRS voltage and increased amplitude of T wave