Management of acute temperomandibular joint arthralgia: a double blind placebo-controlled comparative clinical study

ABSTRACT

Five hundred patients suffering from acute temporomandibular joint arthralgia were entered into a double blind randomized study in an attempt to compare between the efficacy of certain new drugs in the treatment of acute TMJ arthralgia. Patients were divided into five groups; 100 patients each.Nabumetone, indomethacin, azapropazone, tapride or placebo were administred to the patients for six weeks. Joint pain disappeared completely in the majority of patients with much improvement in patients taking tiapride. One year follow-up showed no prompt recurrence of pain in the TMJ region