Effect of diazinon on liver of mice experimentally infected with schistosoma mansoni

ABSTRACT

Diazinon, a broad spectrum non systemic insecticide, of wide range of use in Egypt nowadays, has been used in the present study, in doses comparable to those used in Agriculture and Veterinary Medicine. Parameters of assessment of liver functions were based on biochemical and pathological data. The biochemical changes in blood, reflected the histologic patterns of toxic hepatic injury. A definite logarithmic rise in the serum enzyme level of transaminases [SGOT and SGPT], and also alkaline phosphatase [ALP] was elicited in Diazinon exposed mice whether infected or not. However, Diazinon induced no significant changes in the serum levels regarding total bilirubin, total protein, albumin, globulin and albumin globulin [A/G] ratio. Histopathological examination of the liver tissue of the Diazinon exposed groups of mice, demonstrated necrosis and inflammatory cellular infiltration. However, necrosis in the S. mansoni infected exposed group, was more pronounced; extending from focal to extensive necrosis in accordance to the concentration of the formulation applied. Necrosis was more advanced on using higher concentrations of Diazinon running in parallel to the increase in the serum enzyme levels