effect of pre-operative acute hemodilution on the dose requirements of d-tubo-curarine in patients submitted for radical cystectomy

ABSTRACT

The effect of acute normovolaemic haemodilution [AHD] on the dose requirements of d-tubocurarine was studied in patients submitted for radical cystectomy. They were randomly classified into two groups. Group I [n=10] were given homologous blood [control group], and group II [n=20] were subjected to AHD before induction of anaesthesia. The dose of d-tubocurarine decreased significantly in group II despite the longer duration of action when compared to group I. There was no significant correlation between the dose of d-tubocurarine [mg. kg.[-1] hr.[-1]] required and haemoglobin conc., globulins and albumin in both groups whether before or after anaesthesia and surgery