Some hematological aspects in patients suffering from meningococcal meningitis: special reference to the hemostatic mechanism

ABSTRACT

60 patients with meningococcus meningitis divided into two groups "A" without manifested haemorrhage and "B" with haemorrgagic manifestation. Group "C" represent 30 presumably normal controls. All subjects were thoroughly clinically examined and then subjected to routine laboratory investigations urine, stool, Bl. Picture, biochemical and bacteriological examination of the C.S.F. Special investigations included, bleeding time, coagulation, prothrombin, activated partial thromboplastin thrombin and thromboplastin times, fibrinogen estimations, capillary Hess's test, platelet count and the available platelet function tests. The results revealed increased incidence of shock, marked coagulation defects, normal leucocytic count, normal C.S.F. glucose level and less increase in C.S.F. Protein and C.S.F. Leucocytes in group "B" compared to group "A". The results were discussed. These findings proved to be of prognostic value and may have their benefits in monitoring the cases of bad prognosis to the proper treatment and hence increase the chance of cure