Evaluation of oral glucose tolerance values in different trimesters of pregnancy

ABSTRACT

The present study was conducted to develop evaluation values of oral glucose tolerance in different trimesters of normal and high risk pregnancy. A 75 grams oral glucose tolerance test was performed in 120 pregnant women [90 normal] pregnancy and 30 high risk pregnancy]. Thirty non pregnant married women were also included in the study which acted as controls. Evaluation values were established in normal pregnancy in first trimester [10-12 weeks, n=30] second trimester [22-24 weeks, n=30] and third trimester [30-32 weeks, n=30]. A woman at 32 weeks of gestation repeatedly vomited and was excluded from the study, 3 women of high risk group turned out to be diabetics and were also excluded. There were statistically significant differences between trimester one and two of normal pregnancy group for samples taken 1 hr - 2 hrs and 3 hrs after the glucose load but no significant differences statistically were found between second and third trimester. However, statistically significant differences existed when normal pregnancy group was compared with high risk group in each trimester. The need for the development of reference values of OGTT in different trimesters of pregnancy is stressed