Effects of nifedipine and cimetidine on gastric acidity in rats

ABSTRACT

Effects of nifedipine and cimetidine on gastric acidity were studied in pylorus ligated rats in doses of 0.25 mg, 0.5 mg and 1.0 per Kg given intraperitoneallv. Both drugs inhibited gastric secretions dose dependently. Nifedipine was found to be slightly more effective than cimetidine in raising gastric pH and reducing acidity titratable to 7.0 pH at all dose levels. However, it was less effective in reducing voume of gastric secretions. It is likely that nifedipine has greater anti-ulcer effect than cimetidine in rats