Prevalence of visible retinopathy in Saudi diabetics and its correlation with plasma viscosity and histocompatibility antigens
SJO-Saudi Journal of Ophthalmology. 1991; 5 (4): 179-85
in English
| IMEMR
| ID: emr-22201
ABSTRACT
Of 2341 Saudi diabetic patients registered with the Diabetic Centre at the Ministry of Health in the eastern province of Saudi Arabia, 957 consecutive patients [IDDM = 87, NIDDM = 870] were examined for evidence of retinal changes. One hundred and fifty three [16%] had background retinopathy; maculopathy was seen in eight cases [1%] and 25 patients [3%] had proliferative retinopathy. Thus the combined prevalence of retinopathy in the present series [i. e. IDDM + NIDDM] was approximately 20%. In IDDM, however, it was seen in 32% cases whereas only 18% of the non-insulin dependent group showed these changes. This is in contrast to two previous reports from this country. Highest incidence of retinopathy [68%] was seen only in those who had the disease for 15 years or more. Furthermore, 43% of all diabetics had raised plasma viscosity [ie > 1.73CP]. A greater proportion of patients with retinopathy had increased plasma viscosity as compared with those who had apparently normal retina suggesting its complementary pathogenetic role. Moderately raised plasma viscosity [1.93 - 2.12CP] was however, seen in association with maculopathy in patients with IDDM. However, 15 of the 17 cases with proliferative retinopathy and all 5 cases with maculopathy in patients with NIDDM had moderately raised plasma viscosity. Two cases with proliferative retinopathy in this group had normal viscosity whereas 5 patients with only background retinopathy had moderately raised plasma viscosity. Similarly 7 cases with no retinal changes had for unknown reasons moderately raised plasma viscosity. In 85% of Saudis with IDDM the disease was associated with either HLA DR3, DR4 or both. The prevalence of HLA DR3 appeared more frequent [65%] in Saudi diabetics than their caucasian counterpart [46%] but it was not significantly associated with the prevalence or the severity of retinopathy
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Retina
/
Fluorescein Angiography
/
Blindness
/
Diabetes Mellitus
/
Histocompatibility Antigens
Type of study:
Prevalence study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Saudi J. Ophthalmol.
Year:
1991
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