Tissue reaction to different types of suture materials and techniques used for wounds closure in pregnant rabbit uterus

ABSTRACT

Cesarean section was performed on ten at term pregnant New Zealand white rabbits to compare the macroscopic and microscopic reaction to two types of suture material; polyglactine [Vicryle] and chromic catgut and two types of closure techniques; continuous and locked. In each uterine horn two incisions were made. Each incision was closed according to predetermined method by chromic catgut or Vicryle suture using either continuous or locked technique. After 40 days the animal was sacrificed. Adhesion score was given for each uterine horn. Representative sections from suture site were obtained for histologic evaluation. Microscopically chromic catgut elicited a greater degree of adhesions than Vicryle. Microscopically Vicryle, elicited a lower degree of chronic inflammatory reaction. There was no difference in tissue response betweeen continuous and locked technique. The new synthetic absorbable suture [Vicryle] is an excellent potential alternative to reduce the incidence of post-operative morbidity