experimental study of the effect of cyclosporine: a on normal versus inflamed gingiva

ABSTRACT

The present study was designed to investigate the histological feature inducedby cyclosporin-A [Cs-A] on clinically healthy and induced inflammatorycondition of the gingiva. Twenty four albino rats were used. Silk ligaturewas tighted around the mandibular incisors to act as a local irritating factorin 12 of them. Rats subdivided into two equal groups. Control group injectedwith 30 mg/Kg/body weight of cyclosporin A and included 6 rats with clinicallyhealthy gingiva and other 6 of induced inflamed gingival tissues. The resultsdemonstrated a highly hyperplastic feature in the epithelium associated withincreased collagen deposition with few fibroblasts, inflammatory cellinfiltrates in the underlying connective tissue. No significant difference ofgingival tissue changes or level of protein synthesis were detected betweenclinically healthy and inflamed gingival tissues upon Cs-A medication. It wasconcluded that, Cs-A induced gingival enlargement, and this work provides ananimal model for further investigation of other factors that might contributewith Cs-A in production of gingival over growth