Synthesis of 9-thioureido, cyanoguanidino and nitroethenylamine derivatives of acridines as potential Antimicrobial agents

ABSTRACT

Three series of substituted arcading derivatives, III, IV and VIII were prepared for potential antimicrobial activity. Compounds IIIa-d as the first series were prepared through the reaction of 9-aminoacridine [I] with different alkylisothiocyanates. They were treated with lead cyanamide to give compounds IVa-d of the second series. The reaction of compounds VI with different primary and secondary amines gave compounds VIIIe-I of the third series. The structure of the novel products was substantiated by spectral and microanalytical data. The stereochemistry of the compounds of the third series was studied using nuclear over-hauser enhancement NOE difference. Eight new compounds were in vitro tested for antimicrobial activity