association between plasma lipids and gall stones in patients with ischaemic coronary heart disease

ABSTRACT

The study was conducted on seventy five patients and thirty controls. The patients were classified into three groups Group I included patients with gall stones only, Group II included patients with coronary heart disease CHD only and Group III included those with both diseases. Serum levels of the following lipid fractions were estimated Total cholesterol, phospholipids, tri-glycerides, high density lipoprotein cholesterol, HDL-phospholipids, low density lipo-protein cholesterol and LDL phospholipids. The results showed that the serum total cholesterol was significantly lower in the patients with gall stones compared to controls. The serum phospholipids revealed no difference between patients controls. On the other hand, the serum HDL-cholesterol was significantly lower in all patients than controls. HDL-phospholipids was also lower in the three patient groups in comparison with the controls but this difference is significant in patients with gall stones and in those with CHD. Lastly, the serum level of LDL-cholesterol is significantly higher in all patients than controls LDL phospholipids. The serum level of the LDL-ph was higher in the 3 groups of patients than controls but this difference was significant in Group I and Group III while it was highly significant in Group II compared to controls. The difference between the three groups of patients was insignificant. There is positive correlation in the patient groups and controls as regard the following lipid fractions Total cholesterol versus phospholipids, total cholesterol versus triglycerides, HDL-cholesterol versus HDL-phospholipids and LDL-cholesterol versus LDL-phospholipids. We had observed that there was no significant difference between the 3 groups of patients in any of the estimated lipid fractions and also in the correlation between the above mentioned parameters, so, we can predict that the metabolic effect and the behaviour of both CHD gall stones are the same. Both the serum total cholesterol and the serum phospholipids have no longer been a determinant factors for either CHD or gall stone disease as thought before. However, the serum levels of the lipoproteins are the good predictive indicators for the development of both diseases