Synthesis and effect of new tetrahdronaphthyl pyrazoline on carbohydrate metabolism in bilharzia snails
Bulletin of Faculty of Pharmacy-Cairo University. 1992; 30 (3): 293-296
in English
| IMEMR
| ID: emr-23228
ABSTRACT
A series of 1-acetyl-5-aryl-3-[6-[1,2,3,4-tetrahydronaphthyl]]- delta2-pyrazolines [IIa-f] were synthesized by the reaction of the corresponding 1,2,3,4-tetrahydronaphthalene-chalcones [Ia-f] with hydrazine hydrate in boiling acetic acid. The effect of two of the new delta2-pyrazolines [IIa and IIb] on aerobic oxidation, glucose level, glycogen content and activity of transaminases in Biomphalaria alex and rina snails tissues were determined. The most pronounced effects of these compounds were on the activities of lactate oxidase and pyruvate reductase, while no effect of these compounds was detected on glucose, glycogen and transaminases when used at their LC50 concentration. The relationship between the metabolic effects of these compounds and their molluscicidal activities are discussed
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Schistosoma mansoni
/
Carbohydrates
/
Metabolism
Language:
English
Journal:
Bull. Fac. Pharm.-Cairo Univ.
Year:
1992
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