Synthesis of some 4-substituted-pyrimidinylaminophenyl-6-aryl-1,2,5,6-tetrahydro-2-thioxopyrimidine derivatives as possible antimicrobial agents

ABSTRACT

A novel series of 4-substituted-pyrimidinylaminophenyl-6- aryl -1, 2, 5, 6-tetrahydro-2-thioxopyrimdines was synthesized. Treatment of 2- amino-4- chloro-6- methyl-pyrimidine [Ia] with p-aminoacetophenone afforded the corresponding key intermediate [II]. The latter was reacted with a number of aryl aldehydes to yield the chalcone analogues [III] which undergo cyclocondensation with thiourea to furnish the target compounds [IV]. Preliminary antimicrobial screening showed that some of these novel thioxopyrimidines posses moderate activity against certain gram positive bacteria