Newer 1H- 2-pyrazolines and their related derivatives of anticipated biological activity

ABSTRACT

1 H-delta2-pyrazolines 2 were prepared from the reaction of 2- propen-1-ones 1 with hydrazine hydrate in absolute ethanol at room temperature. Reactions of 2 with acetyl, benzenesulphonyl-, p- toluenesulphonyl-chlorides and ethyl chloroformate gave the corresponding 1-substituted pyrazolines 3 and 4. Compounds 2 reacted also with different isocyanates and isothiocyanates to give carbanilides and thiocarbanilides 5. The pyrazoles 6 were obtained by reaction of the pyrazolines 2 with tetrachloro-O-benzoquinone