HLA-A, -B and -C specificities in osteosarcoma in the Egyptian population

ABSTRACT

HLA-A, -B and -C specificities were determined in 20 osteosarcoma cases and 30 normal subjects, by the microlymphocytotoxicity technique of Terasaki et al. Patients with osteosarcoma showed a trend to increased frequency of HLA-A2, a statistically significant increase of frequency of HLA-A2/A9 combination and HLA-Cw4 specificity. HLA-Aw23 antigen has been completely absent in all cases with osteosarcoma. These findings can be considered in harmony with the view of a genetic contribation, particularly through the HLA system, to the pathogenesis of the disease