Effects of nicotine on pain and aggressivity and antagonism of these effects by mecamylamine
Hamdard Medicus. 1992; 35 (2): 60-65
in English
| IMEMR
| ID: emr-23944
ABSTRACT
Nicotine caused a dose-dependent decrease [1.25 and 2.5 mg/kg] on writhing score of the mice, made painful by intraperitoneal [i.p.] acetic acid injection. At the dose of 0.75 mg/kg i.p. nicotine lowered attack score and time of the mice but there wasn't a significant change at 0.5 mg/kg dosage. These effect of nicotine were blocked by 2.5 mg/kg mecamlamine which was given 15 minutes before nicotine administration
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Pain
/
Aggression
/
Mecamylamine
Limits:
Animals
Language:
English
Journal:
Hamdard Med.
Year:
1992
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