HLA system in childhood acute lymphocytic leukemias [All]

ABSTRACT

In a prior study conducted in Iraq, the major histocompatibility[HLA] antigens were tested in 100 patients with acute lymphocytic leukemias[ALL] in term of increase or a decrease in the frequency of a specific antigen and its association with the prognosis of this disease. A significant increase in the frequency of A33 antigen and a decrease in that of HLA-B27 were noted, while only a numerical increase in that of A2 antigen. A high incidence of A2 antigen observed in patients with a short median survival time and poor prognosis. On the other hand A23+ A 24 [A9- the previous classification] were associated with a very good prognosis and a long median survival time