Athens-like G6PD variant associated with chronic non-spherocytic hemolytic anemia found in Jordan
Jordan Medical Journal. 1992; 26 (1): 77-83
in English
| IMEMR
| ID: emr-24140
ABSTRACT
A G6PD variant associated with hereditary non-spherocytic hemolytic anemia is characterized. The variant which closely resembles Athens-like variant was found in a male member of a family of Palestinian origin. The enzymatic properties were; normal electrophoretic mobility, normal Km NADP + low Km G6PD, increased utilization of substrate analogues, moderate heat stability, and a biphasic pH curve with two peaks at pH 7.0 and 10.0.Athens-like variants resemble the Mediterranean variant of G6PD but can be readily distinguished by the rate of utilization of the substrate analogue deamino-NADP + [about twice less]
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Index:
IMEMR (Eastern Mediterranean)
Language:
English
Journal:
Jordan Med. J.
Year:
1992
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