Study of human and parasitic factors in relation to bancroftian filariasis in Egypt

ABSTRACT

The human leucocytic antigen [HLA] and the histochemical reaction of microfilariae were studied by using cytotoxicity test and microfilarial acid phosphatase activity, respectively, to evaluate the role of the genetic factors and the parasitic factor in the pathogenesis of filariasis. A statistical significant association was found between HLA-B7 and the susceptibility for retaining microfilariae in blood and the development of clinical manifestations of filariasis. Histochemical study reported more or less the same results obtained in Egypt