Ocytogenetic analysts of two multidrugs resistant cancer cells
Journal of the Faculty of Medicine-Baghdad. 1992; 34 (4): 405-13
in English
| IMEMR
| ID: emr-24321
ABSTRACT
A detailed cytogenetic investigation was carried out on two sensitive and resistant cell lines, the human chronic myelogenous Ieukemia [k562] and the human burkitt lymphoma [DAUDI]. These cell lines have shown numerous clonal karyotypic alterations. However, numerical alteration was the more common [most notably chromosome gain]. The resistant sublines-R have shown chromosomal rearrangement unique to the resistant sublines. The k562-R subline was characterized by the presence of homogenous staining region [HSR] located at the long arm of chromosome no. 7 while the DAUD1-R was characterized by the presence of double minute chromosomes [DMs]
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Drug Resistance
/
Leukemia
/
Lymphoma
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
J. Fac. Med.-Baghdad
Year:
1992
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