Arylsulphatase A in the urine of lead intoxicated rabbits

ABSTRACT

A group of 5 male rabbits intoxicated by lead through drinking a solution of lead acetate and a control group of rabbits were included in this study. Urinary arylsulphatase A activity was highly reduced in the lead-intoxicated compared to the control group. This reduction was noted directly after the onset of the intoxication process and was amounting to about 1/10 of the activity found before starting the intoxication course. An in vitro experiment confirmed that lead inhibits the activity of arylsulphatase A in the urine. It is suggested to add this finding as a new test for the early detection of excessive lead absorption