Effect of atropine sulfate ointments and gels on the intraocular pressure of rabbit's eye

ABSTRACT

Atropine sulfate has been formulated in ointments and gels using absorption base, hydrocarbon base, water soluble base, polyvinylpyrrolidone gel and sodium carboxymethylcellulose gel. The release behaviour of the drug and the effect on intraocular pressure of rabbit's eye have been estimated. The results revealed that, the release of atropine sulfate was in the following order, polyvinylpyrrolidone gel > polyethylene glycol > sodium carboxymethylcellulose gel > lanolin-petrolatum > hydrocarbon base. However the maximum effect of drug on intraocular pressure was maintained within three hours in the following order, sodium carboxymethylcellulose gel < hydrocarbon base < polyethylene glycol base < polyvinylpyrrolidone gel < lanolin-petrolatum base