Correlaton between estrogen receptors and histo-pathological parameters in human breast cancer

ABSTRACT

A monoclonal antibodies immunoassay technique was used to demonstrate oestrogen receptors in 50 in freshly excised human breast tumours. 48 cases were infiltrating duct carcinoma and 2 cases were infiltrating lobular carcinoma. The relationship between oestrogen receptors, histopathological type, histopathologicalIy and nuclear grades, fibrosis, elastosis and necrosis was evaluated. Oestrogen receptors positivity was demonstrated in 44 out of 50 cases. A significant positive correlation was found between histopathological and nuclear grades and oestrogen receptors content, well differentiated tumours rarely lacked oestrogen receptors. Tumours with marked fibrosis showed less oestrogen receptors content than tumours with mild fibrosis, Elastotic tumours were more oestrogen receptors positive than non elastotic tumours. Those with marked elastosis showed higher oestrogen receptors content than tumours with moderate and mild elastosis. A significant correlation was found between oestrogen receptors content and necrosis, tumours without necrosis showed higher oestrogen content than those with necrosis. The previous results may explain significant higher 2 year recurrent survival in cases with well differentiated tumours, little fibrosis and absent necrosis found in the present study