Review of treatment 98 cancer larynx patients

ABSTRACT

This study included retrospective analysis for 169 patients of laryngeal carcinoma presented to Kasr EI- Eini Center of Radiation oncology and nuclear Medicine at the period 1985-1989 inclusive. Cancer larynx represented 16.25% of all head and neck tumours and 2.04% of all malignancy at the same period. The aim of this work is to study the response to different treatment modalities and to study recurrence rate, disease free interval and survival period for the patients. Only 98 patients attended for regular follow-up for a period of 18 month. 45 patients received radiation therapy only, 38 patients were treated by surgery plus radiation therapy, 9 patients underwent total laryngectomy, 4 patients were treated by radiation therapy plus chemotherapy and 2 patients were treated by radiation therapy, surgery and chemotherapy. Of this group of patients [40.8%] had no evidence of disease recurrence through that period. Recurrence was observed more in cases treated by radiotherapy only [15%] than those treated by surgery and radiotherapy [7%]. Radiotherapy in combination with surgery or alone in dose higher than 50 Gy had better results specially in treatment of locally advanced lesions [T3 - T4] In conclusion, combined treatment modalities in cancer larynx have direct effect on response to treatment, disease free interval and total survival duration. Tumour size, lymph node status have inverse effect on treatment response, disease free interval and total survival also. Regular follow-up and endoscopic examination is advised for proper assessment and early detection of local recurrence