Physical training ameliotates insulin resistance caused by high fat diet

ABSTRACT

Thirty male-albino rats were segregated equally into three groups according to their dietary fat content and physical training. The first group fed low fat diet [LF] and led sedentary life, the second group fed high fat [HF] diet and led sedentary life, the second group fed [HF] diet but were physically trained. After 6 weeks of dieting and physical training program animals were killed by decapitation, soleus muscle and epididymal pads of fat were taken from all rats and incubated in suitable media. Basal and maximally insulin stimulated glucose uptake by these tissues were estimated. The results of this work demonstrated that both soleus muscle and epididymal pads of fat showed lowered basal and maximally insulin stimulated glucose uptake in the group fed HF diet without physical training compared to the group fed LF diet. By physical training, there is significant enhancement of glucose uptake in the group fed HF diet with physical training. Therefore, insulin resistance induced by high fat diet can be ameliorated by physical training