Complement as a mediator of inflammation in post-streptococcal glomerulonephritis

ABSTRACT

Serum complement C3 and C4 and the immunoglobulins IgG, IgA and IgM were studied in 40 children with post-streptococcal glomerulonephritis. The serum levels of C3 and IgG levels showed significant decrease when compared to a control group of 20 healthy children, while the serum IgM showed significant increase. The decreased C3 and IgG level could be attributed to increased utilization in antigen/antibody complexes. These serum C3, C4 and the 3 classes of immunoglobulins were assayed by automated immunochemical precipitation using the ICS