role of calcium metabolism in the pathogenesis of renal lithiasis

ABSTRACT

Thirty adult patients with renal stones and 10 normal adult persons as a control were studied. They were 19 males and 11 females. Their ages ranged between 16 and 70 years. Hormonal studies revealed a significant rise of serum PTH, with a significant importance in the process of renal lithiasis, whereas other measures showed no significant role. Stone analysis revealed that calcium phosphate stone represented the most common type of stones [46.67%], with calcium content comprising 83.3% of stone matter. The recurrent stones were found in 23.33% of cases and showed a good correlation with an increase in the total serum calcium [P = 0.01]; a decrease of urinary pH [P = 0.04]; and Ca phosphate type of stone [P = 0.04]. Multiple stones were found in 23.33% of cases and showed a good correlation with a low serum calcitonin [P- 0.02] and a low urinary 24 hours proteins [P = 0.05]