site of insulin injection can modify its dose

ABSTRACT

25 insulin dependent diabetes mellitus [IDDM] patients were included in this study to show the effect of insulin injection site on the plasma glucose level. The sites examined were the abdominal wall, the arm and the thigh. The fall of plasma glucose was great with the abdominal injection, intermediate with the arm, and least with the thigh injection. The differences of 2 hour postprandial glucose level in different sites were statistically significant. The 2 hour post prandial mean difference between the abdomen versus the thigh injection sites was 14.9 mg/dl abdomen versus arm injection sties was -8.8 mg/dl and arm versus thigh injection sites was -6 mg/dl. Reduction of glucose level means reduction of insulin dose on changing the site of injection from the thigh to the abdomen by almost 3.3 u from the arm to the abdomen 1.96 u and from the thigh to the arm 1.3 u