[Isoniazid acetylor phenotype in Morocco]

ABSTRACT

A preliminary study of determination of the acetylor phenotype of the izoniazid is achieved for the first time in Morocco in 100 patients. The results have shown a correlation between the methods of determination on blood samples [Delacoux] and urinary ones [Hodgkin] with 59% of quick acetylors and 41% of slow acetylors; these rates are equivalents to those met in Black Africa. The prevalence of the quick acetylors certainly explains the good tolerance of the important doses of the INH [10 mg/kg] used in Morocco. If the determination of the acetylor phenotype cannot be achieved in a systematic way in our country, aiming to an individual adaptation of the posology owing to the calculation of the index of inactivation made on a single swab -, this dosage may on the other hand be achieved in a punctual way against poisoning signs, appeared with a dose of 10mg/kg of INH