Influence of ketonic and ketogenic compounds on potential of carbon tetrachloride hepatotoxicity: Role of ketone bodies

ABSTRACT

The smallest dosage needed to potentiate CCI4 hepatotoxicity was estimated to be between 5.5-11 mm mol/kg/day for BD and 0.95-1.9m mol/kg for MnBk. BD or MnBk also, resulted in a dose dependent metabolic ketosis in the plasma observable at the same dosages which produced potentiation of CCI4 -induced liver injury. This ketonic state was due to an increase in B-hydroxybutyrate [BOHB], while acetoacetate [Ac-Ac] remained at its basal levels. The potentiated response appeared to be related to severity of the metabolic ketosis produced by BD or MnBk. These results suggest that plasma B- hydroxybutyrate concentrations might be useful for predicting possible potentiation of the hepatotoxic effect of CCI4 by BD or MnBk