Atherogenic index, lipoproteins and apolipoproteins A and B levels in hypertensive patients

ABSTRACT

In a comparative study, 21 males recently discovered hypertensive patients [mean 166/110 mm Hg] and 18 male normotensive subjects as a control were studied. Both groups were matched as regard age [mean 53y] and body mass index [32.25]. Intravenous gluscoe tolerance tests [IVGTT] and serum creatinine, urea hepatic transaminases activity [ALT and AST] were done with estimation of serum total cholesterol, triglycerides. HDL LDL and serum apolipoproteins A and B. The results showed normal ALT and AST activity in both groups with mild are impairment in hypertensive groups. Plasma glucose levels showed significant higher levels in the hypertensive group especially at the end of the cure. The mean of serum total cholesterol. HDL and LDL cholesterol levels of hypertensive patients were not significantly different from those of the control. However, the athereogenic index [total cholesterol/HDL cholesterol] was significantly higher n hypertensive group. The serum triglyceride levels were significantly higher than the correplending mean of controls. In hypertensive group there is no significant difference in serumapolipoprotein A but there was significantly higher level of apoliproetein B. Such findings denote the importance of serum triglycerides and therogenic index as well as apolipoprotein B levels as markers for lipoprotein abnormalities in hypertension