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Immuno histochemical study of epithelial and lymphocytic components of adenolymphoma
New Egyptian Journal of Medicine [The]. 1992; 6 (1): 71-75
in English | IMEMR | ID: emr-25280
ABSTRACT
Eighteen cases of adenolymphoma were investigated using 3 immunhistochemical stains to clarify the histogenesis of adenolymphoma Positive immunoreactive cells could be detected in the epithelial component of the tumour using cytokeratin anti-body, thus supporting the concept of its ductal origin. S-100 protein positive cells in-between the epithelial cells and in between the lymphoid stroma could detected using S-100 protein antibody. The morphologic appearance of these cells was identical to that of Langerhan's cells indicating that delayed hypersensitivity may be a pathogenic factor in the development of adenolymphoma. Also, using monoclonal antibody against T-cell fraction, the T-helper cells was more predominant than T-suppressor indicating that the lymphoid stroma was an activated one within the physiological range of normal lymph node. Mast cells were detected in-between the epithelium and in subepithelial stroma by toluidine blue reaction, which may have a direct proliferative effect on the epithelium
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Index: IMEMR (Eastern Mediterranean) Main subject: Lymphocyte Count / Diagnosis / Epithelium Language: English Journal: New Egypt. J. Med. Year: 1992

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Index: IMEMR (Eastern Mediterranean) Main subject: Lymphocyte Count / Diagnosis / Epithelium Language: English Journal: New Egypt. J. Med. Year: 1992